This article outlines a strategic framework developed to enhance neonatal care at the district level. Drawing from diverse country experiences, the model emphasizes the importance of integrating specialized care for small and sick newborns into existing health systems. Key components include establishing functional special care units, training healthcare providers, and ensuring the availability of essential medical supplies and equipment. The model also highlights the need for robust data collection and monitoring to track progress and outcomes. By adopting this comprehensive approach, the initiative aims to significantly reduce neonatal mortality and improve health outcomes for vulnerable newborns globally.